Abstract: At present, the convergence of regional economy and industry in China is prominent, and the differences in industrial structure and layout in various regions are obvious, resulting in the uneven level of regional creative ability. This paper constructs a theoretical analysis framework of factor endowment difference, industry heterogeneity and regional creative ability to analyze the influence of heterogeneous industry structure on regional creative ability improvement, finding that industry heterogeneity can promote the improvement of regional creative ability, heterogeneous capital can promote the increase of market inclusion and creative talents, heterogeneous labor can promote the progress of creative talents and technology, and these effects have a positive feedback multiplier effect.The above conclusions not only supplement the application of industrial organization theory in creative economy, but also verify that labor migration is carried out from the department of single input factors to the department of multiple input factors, and help to clarify the mechanism of industry heterogeneity to improve regional creative ability and creative environment.

Key words: Key words：factor endowment difference, industry heterogeneity, creative ability